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Chembiochem. 2014 Nov 24;15(17):2489-93. doi: 10.1002/cbic.201402432. Epub 2014 Oct 16.

Modular polyketide synthases (PKSs): a new model fits all?

Author information

1
Institute for Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Cluster of Excellence "Macromolecular Complexes", Goethe University Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt/Main (Germany).

Abstract

Step-by-step to great diversity: With the potential to synthesize multi-millions of bioactive compounds, modular polyketide synthases (PKSs) are of great importance. In this Highlight, new developments in the understanding of the structure and function of these proteins are reviewed.

KEYWORDS:

cryo-EM; fatty acids; multienzymes; natural products; polyketides

PMID:
25318851
DOI:
10.1002/cbic.201402432
[Indexed for MEDLINE]

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