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J Neurol Neurosurg Psychiatry. 1989 Nov;52(11):1294-5.

People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.

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1
Department of Psychiatry, Charing Cross and Westminster Medical School, London.

Abstract

The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.

PMID:
2531786
PMCID:
PMC1031641
[Indexed for MEDLINE]
Free PMC Article
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