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J Turk Ger Gynecol Assoc. 2014 Aug 8;15(3):190-6. doi: 10.5152/jtgga.2014.0022. eCollection 2014.

Ovarian aging and premature ovarian failure.

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Department of Obstetrics and Gynecology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Department of Obstetrics and Gynecology, Gazimagusa State Hospital, Gazimagusa, Turkish Republic of Northern Cyprus.
Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.


Physiological reproductive aging occurs as a result of a decrease in the number and quality of oocytes in ovarian cortex follicles. Although the reason for the decrease in the quality of the pool and follicular oocytes is not fully understood, endocrine, paracrine, genetic, and metabolic factors are thought to be effective. Nowadays, in order to understand the mechanisms of ovarian aging, genomic research has gained importance. The effect of co-factors, such as telomerase and ceramide, in the ovarian aging process is only getting ascertained with new research studies. The most important tests in the assessment of ovarian aging are antral follicle count and anti-Mullerian hormone.


Ovarian aging; premature ovarian failure; reproduction

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