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J Infect Dis. 2014 Nov 1;210 Suppl 1:S447-53. doi: 10.1093/infdis/jiu043.

Progress in the development of poliovirus antiviral agents and their essential role in reducing risks that threaten eradication.

Author information

1
Center for Vaccine Equity, The Task Force for Global Health, Decatur, Georgia ViroDefense Inc., Rockville, Maryland Centers for Disease Control and Prevention, Atlanta, Georgia World Health Organization, Geneva, Switzerland Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire Center for Vaccine Equity, Task Force for Global Health, Decatur, Georgia.
2
ViroDefense Inc., Rockville, Maryland.
3
Centers for Disease Control and Prevention, Atlanta, Georgia.
4
World Health Organization, Geneva, Switzerland.
5
Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
6
Center for Vaccine Equity, Task Force for Global Health, Decatur, Georgia.

Abstract

Chronic prolonged excretion of vaccine-derived polioviruses by immunodeficient persons (iVDPV) presents a personal risk of poliomyelitis to the patient as well as a programmatic risk of delayed global eradication. Poliovirus antiviral drugs offer the only mitigation of these risks. Antiviral agents may also have a potential role in the management of accidental exposures and in certain outbreak scenarios. Efforts to discover and develop poliovirus antiviral agents have been ongoing in earnest since the formation in 2007 of the Poliovirus Antivirals Initiative. The most advanced antiviral, pocapavir (V-073), is a capsid inhibitor that has recently demonstrated activity in an oral poliovirus vaccine human challenge model. Additional antiviral candidates with differing mechanisms of action continue to be profiled and evaluated preclinically with the goal of having 2 antivirals available for use in combination to treat iVDPV excreters.

KEYWORDS:

antiviral; poliovirus

PMID:
25316866
DOI:
10.1093/infdis/jiu043
[Indexed for MEDLINE]

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