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Nat Rev Neurosci. 2014 Nov;15(11):757-64. doi: 10.1038/nrn3811. Epub 2014 Oct 15.

Early phytocannabinoid chemistry to endocannabinoids and beyond.

Author information

1
Institute for Drug Research, Medical Faculty, Hebrew University, Jerusalem, 91120, Israel.
2
Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK.
3
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, One Medical Center Blvd, Winston-Salem, North Carolina 27157, USA.

Abstract

Isolation and structure elucidation of most of the major cannabinoid constituents--including Δ(9)-tetrahydrocannabinol (Δ(9)-THC), which is the principal psychoactive molecule in Cannabis sativa--was achieved in the 1960s and 1970s. It was followed by the identification of two cannabinoid receptors in the 1980s and the early 1990s and by the identification of the endocannabinoids shortly thereafter. There have since been considerable advances in our understanding of the endocannabinoid system and its function in the brain, which reveal potential therapeutic targets for a wide range of brain disorders.

PMID:
25315390
DOI:
10.1038/nrn3811
[Indexed for MEDLINE]

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