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Nat Rev Mol Cell Biol. 2014 Nov;15(11):703-8. doi: 10.1038/nrm3890. Epub 2014 Oct 15.

Histone core modifications regulating nucleosome structure and dynamics.

Author information

1
Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK; and the Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany.
2
Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK.

Abstract

Post-translational modifications of histones regulate all DNA-templated processes, including replication, transcription and repair. These modifications function as platforms for the recruitment of specific effector proteins, such as transcriptional regulators or chromatin remodellers. Recent data suggest that histone modifications also have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone-histone and histone-DNA interactions, as well as the binding of histones to chaperones.

PMID:
25315270
DOI:
10.1038/nrm3890
[Indexed for MEDLINE]

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