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Zygote. 2015 Dec;23(6):951-4. doi: 10.1017/S0967199414000562. Epub 2014 Oct 15.

Investigation of histone H4 hyperacetylation dynamics in the 5S rRNA genes family by chromatin immunoprecipitation assay.

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University of Bucharest,Genetics Department,Bucharest,Romania.


Oogenesis is a critical event in the formation of female gamete, whose role in development is to transfer genomic information to the next generation. During this process, the gene expression pattern changes dramatically concomitant with genome remodelling, while genomic information is stably maintained. The aim of the present study was to investigate the presence of H4 acetylation of the oocyte and somatic 5S rRNA genes in Triturus cristatus, using chromatin immunoprecipitation assay (ChIP). Our findings suggest that some epigenetic mechanisms such as histone acetylation could be involved in the transcriptional regulation of 5S rRNA gene families.


5S rDNA; ChIP assay; H4 hyperacetylation; Triturus cristatus; oocytes

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