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Pharmacol Biochem Behav. 1989 Jul;33(3):627-31.

8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine.

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Department of Pharmacology and Toxicology, Wright State University, Dayton, OH.
Wright St U, Dayton, OH


Vomiting was suppressed in cats pretreated with 8-OH-DPAT and then challenged with an emetic stimulus; motion, xylazine or cisplatin. The antiemetic effect is likely due to stimulation of postsynaptic serotonin-1A receptors. The most parsimonious explanation is that it acts at a convergent structure, presumably at or near the vomiting center. If so, 8-OH-DPAT may block emesis elicited by virtually any other stimulus. A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis. These results do not support the possibility that the antiemetic effects of 8-OH-DPAT were the result of anxiolytic activity.

[Indexed for MEDLINE]

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