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Expert Rev Anti Infect Ther. 2014 Dec;12(12):1487-99. doi: 10.1586/14787210.2014.970634. Epub 2014 Oct 14.

Melioidosis: molecular aspects of pathogenesis.

Author information

1
Department of Microbiology and Immunology, University of South Alabama, 610 Clinic Drive, Mobile, AL 36688, USA.

Abstract

Burkholderia pseudomallei is a gram-negative bacterium that causes melioidosis, a multifaceted disease that is highly endemic in southeast Asia and northern Australia. This facultative intracellular pathogen possesses a large genome that encodes a wide array of virulence factors that promote survival in vivo by manipulating host cell processes and disarming elements of the host immune system. Antigens and systems that play key roles in B. pseudomallei virulence include capsular polysaccharide, lipopolysaccharide, adhesins, specialized secretion systems, actin-based motility and various secreted factors. This review provides an overview of the current and steadily expanding knowledge regarding the molecular mechanisms used by this organism to survive within a host and their contribution to the pathogenesis of melioidosis.

KEYWORDS:

Burkholderia pseudomallei; capsule; facultative intracellular pathogen; lipopolysaccharide; melioidosis; pathogenesis; secretion systems; virulence factors

PMID:
25312349
PMCID:
PMC4409121
DOI:
10.1586/14787210.2014.970634
[Indexed for MEDLINE]
Free PMC Article

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