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Cell Mol Biol Lett. 2014 Dec;19(4):561-75. doi: 10.2478/s11658-014-0212-6. Epub 2014 Oct 13.

Regulation of lncRNA expression.

Author information

1
Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China.

Abstract

Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.

PMID:
25311814
PMCID:
PMC6275606
DOI:
10.2478/s11658-014-0212-6
[Indexed for MEDLINE]
Free PMC Article

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