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J Biosci Bioeng. 2015 Apr;119(4):464-9. doi: 10.1016/j.jbiosc.2014.09.008. Epub 2014 Oct 12.

Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents.

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Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC.
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. Electronic address:


In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We developed bioactive effects of P. cuspidatum extracts via multiple examinations that established bio-purposes at a range of dosage ranges. The research of P. cuspidatum extracts indicated that they possessed anti-oxidative properties on radical-scavenging abilities, reducing activities and metal chelating powers in dose-dependant manners. The extracts also had minor in vitro mushroom tyrosinase suppression and decreased cellular tyrosinase activities and melanin production in B16-F10 cells. Immunologically, P. cuspidatum extracts enhanced the release of tumor necrosis factor α (TNF-α) induced by THP-1 macrophage cell line. In addition, the cell proliferation showed anti-proliferation in dose-dependent manner on human skin melanoma cells, A375 and A375.S2, of the extracts suggesting biological constitutes employed the anti-cancer possessions. This is the first statement presenting bioactivities on P. cuspidatum extracts including anti-oxidation, immune stimulation, anti-tyrosinase and anti-melanoma as far as we know.


Anti-cancer; Anti-tyrosinase; Antioxidant; Immune; Polygonum cuspidatum; Supercritical fluid carbon dioxide extraction

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