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J Biosci Bioeng. 2015 Apr;119(4):464-9. doi: 10.1016/j.jbiosc.2014.09.008. Epub 2014 Oct 12.

Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents.

Author information

1
Department of Chemical Engineering, National Chung Hsing University, Taichung, Taiwan, ROC.
2
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
3
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
4
Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. Electronic address: davidw@kmu.edu.tw.

Abstract

In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We developed bioactive effects of P. cuspidatum extracts via multiple examinations that established bio-purposes at a range of dosage ranges. The research of P. cuspidatum extracts indicated that they possessed anti-oxidative properties on radical-scavenging abilities, reducing activities and metal chelating powers in dose-dependant manners. The extracts also had minor in vitro mushroom tyrosinase suppression and decreased cellular tyrosinase activities and melanin production in B16-F10 cells. Immunologically, P. cuspidatum extracts enhanced the release of tumor necrosis factor α (TNF-α) induced by THP-1 macrophage cell line. In addition, the cell proliferation showed anti-proliferation in dose-dependent manner on human skin melanoma cells, A375 and A375.S2, of the extracts suggesting biological constitutes employed the anti-cancer possessions. This is the first statement presenting bioactivities on P. cuspidatum extracts including anti-oxidation, immune stimulation, anti-tyrosinase and anti-melanoma as far as we know.

KEYWORDS:

Anti-cancer; Anti-tyrosinase; Antioxidant; Immune; Polygonum cuspidatum; Supercritical fluid carbon dioxide extraction

PMID:
25311751
DOI:
10.1016/j.jbiosc.2014.09.008
[Indexed for MEDLINE]

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