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Res Vet Sci. 2014 Dec;97(3):574-81. doi: 10.1016/j.rvsc.2014.09.011. Epub 2014 Sep 28.

A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: a randomized placebo-controlled trial.

Author information

1
Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
2
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
3
Department of Pathology and Microbiology - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada.
4
Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada. Electronic address: eric.troncy@umontreal.ca.

Abstract

An oral herb-based natural health product (NHP) was evaluated in the canine natural osteoarthritis model. At baseline, the peak vertical force (PVF, primary endpoint) and case-specific outcome measure of disability (CSOM) were recorded in privately-owned dogs. Dogs (16/group) were randomized to receive NHP formulations or a negative control. The PVF was measured at week (W) 4 and W8. Daily locomotor activity was recorded using accelerometer. The CSOMs were assessed bi-weekly by the owner. The NHP-treated dogs (n = 13) had higher PVF at W4 (p = 0.020) and W8 (p <0.001) when compared to baseline. The changes at W8 were higher than control dogs (n = 14, p <0.027) and consistent with Cohen's d effect size of 0.7 (95% confidence interval: 0.0-1.5). The NHP-treated dogs had higher locomotor activity at W8 (p = 0.025) when compared to baseline. No significant change was observed for the CSOM. The NHP improved the clinical signs of osteoarthritis in this model.

KEYWORDS:

Canine model; Force platform; Locomotor activity; Naturally-occurring osteoarthritis; Phytochemical compounds

PMID:
25311158
DOI:
10.1016/j.rvsc.2014.09.011
[Indexed for MEDLINE]

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