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Adv Exp Med Biol. 2015;836:19-28. doi: 10.1007/5584_2014_22.

Effectiveness of immunoprophylaxis in suppressing carriage of Neisseria meningitidis in the military environment.

Author information

1
Department of Epidemiology and Tropical Medicine, Military Institute of Medicine, 4 Grudzińskiego St., Gdynia, 81-103, Poland, kktropmed@wp.pl.

Abstract

Neisseria meningitidis, etiological factor of invasive meningococcal disease, is a human commensal that colonizes the nasopharynx. Colonization is usually asymptomatic, but it is a prerequisite for disease. Asymptomatic carriers are the major source of infection. In the present study, a survey of N. meningitidis carriage was conducted between January and March 2013 in a military unit in Poland. Single-time throat culture samples were collected from professional 559 soldiers (302 unvaccinated vs. 257 vaccinated individuals with the quadrivalent conjugate vaccine ACYW-135). Bacterial identification was performed with classic microbiological methods (culture, incubation, identification). Non-culture method (PCR) was used for confirmation of detected strains of N. meningitidis and determination of serogroups. We found 29 carriers in the group of unvaccinated soldiers (9.6 % of examined individuals) whereas among vaccinated soldiers only 3 persons were carriers of N. meningitidis (1.2 %). The most frequently identified serogroups among the carriers serving in the same military facility were serogroup B (28 %), followed by Y (25 %), and C (22 %). In conclusion, the initiation of mass vaccination with the quadrivalent conjugate vaccine ACYW-135 in the military environment seems an effective method of suppressing N. meningitidis carriage.

PMID:
25310944
DOI:
10.1007/5584_2014_22
[Indexed for MEDLINE]

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