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Curr Opin Neurobiol. 2014 Dec;29:178-86. doi: 10.1016/j.conb.2014.09.010. Epub 2014 Oct 10.

Neural control of brain state.

Author information

1
Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, United States.
2
Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, United States. Electronic address: david.mccormick@yale.edu.

Abstract

How the brain takes in information, makes a decision, and acts on this decision is strongly influenced by the ongoing and constant fluctuations of state. Understanding the nature of these brain states and how they are controlled is critical to making sense of how the nervous system operates, both normally and abnormally. While broadly projecting neuromodulatory systems acting through metabotropic pathways have long been appreciated to be critical for determining brain state, more recent investigations have revealed a prominent role for fast acting neurotransmitter pathways for temporally and spatially precise control of neural processing. Corticocortical and thalamocortical glutamatergic projections can rapidly and precisely control brain state by changing both the nature of ongoing activity and by controlling the gain and precision of neural responses.

PMID:
25310628
PMCID:
PMC4254046
DOI:
10.1016/j.conb.2014.09.010
[Indexed for MEDLINE]
Free PMC Article

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