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J Immunol Res. 2014;2014:164309. doi: 10.1155/2014/164309. Epub 2014 Sep 21.

Powering the immune system: mitochondria in immune function and deficiency.

Author information

1
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
2
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, 16147 Genova, Italy.
3
Division of Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA 02114, USA.
4
Novartis Institute for Research in Biomedicine, Basel, Switzerland.

Abstract

Mitochondria are critical subcellular organelles that are required for several metabolic processes, including oxidative phosphorylation, as well as signaling and tissue-specific processes. Current understanding of the role of mitochondria in both the innate and adaptive immune systems is expanding. Concurrently, immunodeficiencies arising from perturbation of mitochondrial elements are increasingly recognized. Recent observations of immune dysfunction and increased incidence of infection in patients with primary mitochondrial disorders further support an important role for mitochondria in the proper function of the immune system. Here we review current findings.

PMID:
25309931
PMCID:
PMC4189529
DOI:
10.1155/2014/164309
[Indexed for MEDLINE]
Free PMC Article

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