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Front Neural Circuits. 2014 Sep 12;8:112. doi: 10.3389/fncir.2014.00112. eCollection 2014.

Input clustering and the microscale structure of local circuits.

Author information

1
Center for Neuroscience, Department of Neurobiology, Physiology and Behavior, University of California-Davis Davis, CA, USA.
2
Center for Neuroscience, Department of Neurobiology, Physiology and Behavior, University of California-Davis Davis, CA, USA ; PLOS Medicine San Francisco, CA, USA.

Abstract

The recent development of powerful tools for high-throughput mapping of synaptic networks promises major advances in understanding brain function. One open question is how circuits integrate and store information. Competing models based on random vs. structured connectivity make distinct predictions regarding the dendritic addressing of synaptic inputs. In this article we review recent experimental tests of one of these models, the input clustering hypothesis. Across circuits, brain regions and species, there is growing evidence of a link between synaptic co-activation and dendritic location, although this finding is not universal. The functional implications of input clustering and future challenges are discussed.

KEYWORDS:

clustered plasticity; connectome; dendritic integration; synapse clustering; synaptic clustering

PMID:
25309336
PMCID:
PMC4162353
DOI:
10.3389/fncir.2014.00112
[Indexed for MEDLINE]
Free PMC Article

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