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Aphasiology. 2014 Aug;28(8-9):1004-1017.

Motor Speech Disorders Associated with Primary Progressive Aphasia.

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Dept. of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, U.S.A.



Primary progressive aphasia (PPA) and conditions that overlap with it can be accompanied by motor speech disorders. Recognition and understanding of motor speech disorders can contribute to a fuller clinical understanding of PPA and its management as well as its localization and underlying pathology.


To review the types of motor speech disorders that may occur with PPA, its primary variants, and its overlap syndromes (progressive supranuclear palsy syndrome, corticobasal syndrome, motor neuron disease), as well as with primary progressive apraxia of speech.


The review should assist clinicians' and researchers' understanding of the relationship between motor speech disorders and PPA and its major variants. It also highlights the importance of recognizing neurodegenerative apraxia of speech as a condition that can occur with little or no evidence of aphasia.


Motor speech disorders can occur with PPA. Their recognition can contribute to clinical diagnosis and management of PPA and to understanding and predicting the localization and pathology associated with PPA variants and conditions that can overlap with them.


apraxia of speech; dysarthrias; motor speech disorders; primary progressive aphasia; primary progressive apraxia of speech

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