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Curr Opin Biotechnol. 2015 Apr;32:14-20. doi: 10.1016/j.copbio.2014.09.005. Epub 2014 Oct 8.

The small intestine microbiota, nutritional modulation and relevance for health.

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TI Food and Nutrition, Wageningen, The Netherlands; Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt.
TI Food and Nutrition, Wageningen, The Netherlands; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
TI Food and Nutrition, Wageningen, The Netherlands; Host-Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands; NIZO Food Research, Ede, The Netherlands. Electronic address:


The intestinal microbiota plays a profound role in human health and extensive research has been dedicated to identify microbiota aberrations that are associated with disease. Most of this work has been targeting the large intestine and fecal microbiota, while the small intestine microbiota may also have a profound impact on various aspects of the host's physiology, including immune, metabolic and endocrine functions. This review highlights the recent advances made in the study of the human small intestine microbiota. In addition, it describes recent human and animal studies that underpin the importance of this part of the intestine for health of the host organism.

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