Format

Send to

Choose Destination
Chemistry. 2014 Nov 17;20(47):15334-8. doi: 10.1002/chem.201405223. Epub 2014 Oct 13.

Copper-catalyzed reductive cross-coupling of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides.

Author information

1
Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P. R. China); State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou (P. R. China); Department of Chemistry, Tsinghua University, Beijing 100084 (P. R. China).

Abstract

A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl CC bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo- or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.

KEYWORDS:

CC bond formation; catalysis; copper; cross-coupling; cyclization

PMID:
25308802
DOI:
10.1002/chem.201405223

Supplemental Content

Loading ...
Support Center