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Immunity. 2014 Oct 16;41(4):592-604. doi: 10.1016/j.immuni.2014.09.009. Epub 2014 Oct 9.

C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.

Author information

1
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, TX 75204, USA.
2
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, TX 75204, USA; Baylor University, Institute for Biomedical Studies, South 5th Street, Waco, TX 76706, USA.
3
Division of Immuno-Virology, Institute of Emerging Diseases and Innovative Therapies, Commissariat á l'Energie Atomique, Paris 922655, France.
4
Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433-8915, USA.
5
Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, TX 75204, USA; Baylor University, Institute for Biomedical Studies, South 5th Street, Waco, TX 76706, USA. Electronic address: sangkono@baylorhealth.edu.

Abstract

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a pattern-recognition receptor for a variety of endogenous and exogenous ligands. However, LOX-1 function in the host immune response is not fully understood. Here, we report that LOX-1 expressed on dendritic cells (DCs) and B cells promotes humoral responses. On B cells LOX-1 signaling upregulated CCR7, promoting cellular migration toward lymphoid tissues. LOX-1 signaling on DCs licensed the cells to promote B cell differentiation into class-switched plasmablasts and led to downregulation of chemokine receptor CXCR5 and upregulation of chemokine receptor CCR10 on plasmablasts, enabling their exit from germinal centers and migration toward local mucosa and skin. Finally, we found that targeting influenza hemagglutinin 1 (HA1) subunit to LOX-1 elicited HA1-specific protective antibody responses in rhesus macaques. Thus, LOX-1 expressed on B cells and DC cells has complementary functions to promote humoral immune responses.

PMID:
25308333
PMCID:
PMC4221489
DOI:
10.1016/j.immuni.2014.09.009
[Indexed for MEDLINE]
Free PMC Article

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