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Curr Opin Pharmacol. 2014 Oct;18:104-11. doi: 10.1016/j.coph.2014.09.017. Epub 2014 Oct 10.

Novel aspects of encapsulation and delivery using polymersomes.

Author information

1
Department of Chemistry and The MRC/UCL Centre for Medical Molecular Virology, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
2
Department of Chemistry and The MRC/UCL Centre for Medical Molecular Virology, University College London, 20 Gordon Street, London WC1H 0AJ, UK. Electronic address: g.battaglia@ucl.ac.uk.

Abstract

Polymersomes are nanoscopic (e.g. nanometer-sized) vesicles formed by amphiphilic block copolymers. They represent the more robust and versatile macromolecular counterparts to the well-established lipid vesicles or liposomes. Recently, considerable efforts have been made to produce them in a uniform and functional manner. New techniques such as artificial endocytosis and electroporation have also been developed to achieve payload encapsulation. In this mini-review, we discuss these and other recent developments in making polymersomes an actual alternative for biomedical applications.

PMID:
25306248
DOI:
10.1016/j.coph.2014.09.017
[Indexed for MEDLINE]

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