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Nat Biotechnol. 2014 Nov;32(11):1134-40. doi: 10.1038/nbt.3020. Epub 2014 Oct 12.

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.

Author information

1
1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
2
1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
3
1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
4
1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
5
1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
6
Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
7
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
8
1] Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
9
1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.

Abstract

Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.

PMID:
25306244
DOI:
10.1038/nbt.3020
[Indexed for MEDLINE]

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