Format

Send to

Choose Destination
Appl Radiat Isot. 2014 Dec;94:349-354. doi: 10.1016/j.apradiso.2014.09.006. Epub 2014 Sep 18.

Preparation of the metabotropic glutamate receptor 5 (mGluR5) PET tracer [(18)F]FPEB for human use: An automated radiosynthesis and a novel one-pot synthesis of its radiolabeling precursor.

Author information

1
PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: Keunpoong.Lim@yale.edu.
2
PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

The radiotracer 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile, or [(18)F]FPEB, is a promising PET imaging agent for the metabotropic glutamate subtype 5 receptor (mGluR5). In an effort to develop a routine production method of this radiotracer for use in clinical research we adapted its radiosynthesis to an automated chemistry module. In the meanwhile, we also developed a simplified "one-pot" method for the preparation of the nitrobenzonitrile radiolabeling precursor for [(18)F]FPEB and its reference standard to replace the existing multi-step synthetic approach.

KEYWORDS:

PET; Radiotracer synthesis; Suzuki coupling; [(18)F]FPEB; mGluR5

PMID:
25305528
PMCID:
PMC4253068
DOI:
10.1016/j.apradiso.2014.09.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center