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Clin Infect Dis. 2014 Nov 1;59 Suppl 4:S225-32. doi: 10.1093/cid/ciu413.

Microbiologic methods utilized in the MAL-ED cohort study.

Author information

1
University of Virginia, Charlottesville.
2
Johns Hopkins University, Baltimore, Maryland.
3
Aga Khan University, Naushahro Feroze, Pakistan.
4
Christian Medical College, Vellore, India.
5
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
6
University of Venda, Thohoyandou, South Africa.
7
Universidade Federal do Ceara, Fortaleza, Brazil.
8
icddr,b, Dhaka, Bangladesh.
9
Fogarty International Center, National Institutes of Health.
10
Fogarty International Center, National Institutes of Health Foundation of the National Institutes of Health, Bethesda, Maryland.

Abstract

A central hypothesis of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) study is that enteropathogens contribute to growth faltering. To examine this question, the MAL-ED network of investigators set out to achieve 3 goals: (1) develop harmonized protocols to test for a diverse range of enteropathogens, (2) provide quality-assured and comparable results from 8 global sites, and (3) achieve maximum laboratory throughput and minimum cost. This paper describes the rationale for the microbiologic assays chosen and methodologies used to accomplish the 3 goals.

KEYWORDS:

ELISA; PCR; culture; enteropathogen; microscopy

PMID:
25305291
PMCID:
PMC4204609
DOI:
10.1093/cid/ciu413
[Indexed for MEDLINE]
Free PMC Article

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