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Mult Scler. 2015 May;21(6):703-9. doi: 10.1177/1352458514551780. Epub 2014 Oct 10.

Risk factors for multiple sclerosis, neuromyelitis optica and transverse myelitis.

Author information

1
Department of Nutrition, Harvard School of Public Health, USA/Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, USA.
2
Accelerated Cure Project, USA.
3
Department of Nutrition, Harvard School of Public Health, USA/Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, USA/Department of Epidemiology, Harvard School of Public Health, USA aascheri@hsph.harvard.edu.

Abstract

BACKGROUND:

Little is known about risk factors for neuromyelitis optica (NMO) or transverse myelitis (TM).

OBJECTIVE:

The objective of this paper is to evaluate whether established multiple sclerosis (MS) risk factors, including smoking history, a history of infectious mononucleosis (IM), anti-EBNA1 Ab titers and HLA-DR15 are associated with NMO or TM.

METHODS:

We conducted a case-control study among participants in the Accelerated Cure Project for Multiple Sclerosis (ACP) Repository, which includes patients with MS, NMO and TM. Controls include related and unrelated individuals without evidence of demyelinating disease. Analyses included 1237 cases of MS, 98 cases of NMO, 133 cases of TM and 488 healthy controls. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to assess the association between smoking, HLA-DR15, anti-EBNA1 Ab titers and a history of IM adjusting for gender, study site and ethnicity.

RESULTS:

Overall, the association between smoking, IM, HLA-DR15 and anti-EBNA1 Ab titers and odds of MS were as expected and no significant interactions were observed. However, there was little evidence of association between these MS risk factors and odds of NMO or TM.

CONCLUSIONS:

Established MS risk factors do not appear to be associated with susceptibility to TM or NMO and, among MS patients, these risk factors appear to act independently.

KEYWORDS:

Epstein-Barr virus; Multiple sclerosis; all demyelinating disease (CNS); case control studies; neuromyelitis optica; risk factors in epidemiology; transverse myelitis

PMID:
25305254
DOI:
10.1177/1352458514551780
[Indexed for MEDLINE]

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