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Cancer Lett. 2015 Jan 28;356(2 Pt B):483-90. doi: 10.1016/j.canlet.2014.09.032. Epub 2014 Oct 7.

TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma.

Author information

1
Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China. Electronic address: wbwb1620@163.com.
2
Department of Oncology, General Hospital, Jinan Command of the People's Liberation Army, Jinan, 250031, China.
3
Center for Disease Control, Jinan Command of the People's Liberation Army, Jinan, 250014, China.
4
Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
5
Department of Oncology, the 148th Hospital, Jinan Command of the People's Liberation Army, Zibo, 255300, China.
6
Department of Rheumatology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.

Abstract

Our study observed the relationship between transient receptor potential melastatin 7 (TRPM7) expression and the metastatic process of nasopharyngeal carcinoma (NPC). We found that TRPM7 was overexpressed in 102 out of 206 (49.5%) human NPC cases and was significantly associated with clinical stage and lymphatic and distant metastasis. The results suggested that TRPM7 promotes NPC cell migration and invasion in vitro. Further, TRPM7 was correlated with poor clinical outcome and was an independent predictor for 5-year overall survival rate (HR, 1.832; 95% CI, 1.237-4.146 [Pā€‰=ā€‰0.041]). In conclusion, TRPM7 promotes the metastasis of NPC and may serve as a prognostic marker in NPC patients.

KEYWORDS:

Metastasis; Migration; Nasopharyngeal carcinoma; Prognosis; TRPM7

PMID:
25304381
DOI:
10.1016/j.canlet.2014.09.032
[Indexed for MEDLINE]

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