Format

Send to

Choose Destination
Int J Infect Dis. 2014 Dec;29:301-6. doi: 10.1016/j.ijid.2014.09.003. Epub 2014 Oct 7.

Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia.

Author information

1
Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
2
Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia; King Saud University, Riyadh, Kingdom of Saudi Arabia.
3
Department of Infection Prevention and Control, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
4
Department of Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
5
Department of Family and Community Medicine, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
6
Department of Radiology, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
7
Division of Infectious Diseases, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia; Department of Infection Prevention and Control, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.
8
Ministry of Health & college of Medicine, Al-Faisal University, Riyadh, Kingdom of Saudi Arabia. Electronic address: zmemish@yahoo.com.

Abstract

OBJECTIVES:

To report the experience with Middle East respiratory syndrome coronavirus (MERS-CoV) infection at a single center in Saudi Arabia.

METHODS:

Cases of laboratory-confirmed MERS-CoV occurring from October 1, 2012 to May 31, 2014 were reviewed retrospectively. Information sources included medical files, infection control outbreak investigations, and the preventive medicine database of MERS-CoV-infected patients. Data were collected on clinical and epidemiological aspects and outcomes.

RESULTS:

Seventy consecutive patients were included. Patients were mostly of older age (median 62 years), male (46, 65.7%), and had healthcare acquisition of infection (39, 55.7%). Fever (43, 61.4%), dyspnea (42, 60%), and cough (38, 54.3%) were the most common symptoms. The majority developed pneumonia (63, 90%) and required intensive care (49, 70%). Infection commonly occurred in clusters. Independent risk factors for severe infection requiring intensive care included concomitant infections (odds ratio (OR) 14.13, 95% confidence interval (CI) 1.58-126.09; p=0.018) and low albumin (OR 6.31, 95% CI 1.24-31.90; p=0.026). Mortality was high (42, 60%), and age ≥65 years was associated with increased mortality (OR 4.39, 95% CI 2.13-9.05; p<0.001).

CONCLUSIONS:

MERS-CoV can cause severe infection requiring intensive care and has a high mortality. Concomitant infections and low albumin were found to be predictors of severe infection, while age ≥65 years was the only predictor of increased mortality.

KEYWORDS:

Clinical; Epidemiology; Middle East respiratory syndrome coronavirus (MERS-CoV); Saudi Arabia

PMID:
25303830
DOI:
10.1016/j.ijid.2014.09.003
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center