Format

Send to

Choose Destination
FEBS J. 2015 May;282(9):1647-57. doi: 10.1111/febs.13101. Epub 2014 Nov 7.

The many faces of long noncoding RNAs.

Author information

1
Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, FL, USA.

Abstract

Over the past few years, the field of noncoding RNAs has grown from a niche for geneticists into a prominent domain of mainstream biology. Advances in genomic technologies have provided a more comprehensive view of the mammalian genome, improving our knowledge of regions of the genome devoid of protein-coding potential. A large body of evidence supports the proposal that noncoding RNAs account for a large proportion of the transcriptional output of any given cell and tissue type. This review will delve into the biogenesis and function of long noncoding RNAs. We will discuss our current understanding of these molecules as major chromatin players, and explore future directions in the field.

KEYWORDS:

eRNAs; enhancer; lncRNAs; noncoding; transcription

PMID:
25303371
PMCID:
PMC4520312
DOI:
10.1111/febs.13101
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center