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Korean J Anesthesiol. 2014 Sep;67(3):164-70. doi: 10.4097/kjae.2014.67.3.164. Epub 2014 Sep 24.

Postoperative nausea and vomiting.

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Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, Catholic University College of Medicine, Seoul, Korea.


Postoperative nausea and vomiting (PONV) is a long-standing issue, not a new concept in anesthesiology. Despite many studies over the last several decades, PONV remains a significant problem due to its complex mechanism. This review presents a summary of the mechanism underlying the pathogenesis of PONV, focusing on preventive treatment, particularly the use of new drugs. In addition, we discuss the latest meta-analysis results regarding correct clinical use of classic drugs. I also summarize the latest trends of postdischarge nausea and vomiting and the pharmacogenetics, which is attracting a great deal of attention from other medical fields in PONV-related studies. Finally, we discuss the drawbacks of existing studies on PONV and suggest a focus for future investigations.


Postdischarge nausea and vomiting; Postoperative nausea and vomiting; Prevention

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