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Science. 2014 Nov 7;346(6210):1258361. doi: 10.1126/science.1258361. Epub 2014 Oct 9.

Casting inorganic structures with DNA molds.

Author information

1
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
2
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
3
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
4
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. py@hms.harvard.edu mark.bathe@mit.edu.
5
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. py@hms.harvard.edu mark.bathe@mit.edu.

Abstract

We report a general strategy for designing and synthesizing inorganic nanostructures with arbitrarily prescribed three-dimensional shapes. Computationally designed DNA strands self-assemble into a stiff "nanomold" that contains a user-specified three-dimensional cavity and encloses a nucleating gold "seed." Under mild conditions, this seed grows into a larger cast structure that fills and thus replicates the cavity. We synthesized a variety of nanoparticles with 3-nanometer resolution: three distinct silver cuboids with three independently tunable dimensions, silver and gold nanoparticles with diverse cross sections, and composite structures with homo- and heterogeneous components. The designer equilateral silver triangular and spherical nanoparticles exhibited plasmonic properties consistent with electromagnetism-based simulations. Our framework is generalizable to more complex geometries and diverse inorganic materials, offering a range of applications in biosensing, photonics, and nanoelectronics.

PMID:
25301973
PMCID:
PMC4260265
DOI:
10.1126/science.1258361
[Indexed for MEDLINE]
Free PMC Article

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