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Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):40-9. doi: 10.1161/ATVBAHA.114.303227. Epub 2014 Oct 9.

Lymphocyte migration into atherosclerotic plaque.

Author information

1
From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA.
2
From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA. klaus@liai.org.

Abstract

Adaptive immunity is involved in the pathogenesis of atherosclerosis, but the recruitment of T and B lymphocytes to atherosclerotic lesions is not as well studied as that of monocytes. In this review, we summarize the current understanding of the role of lymphocyte subsets in the pathogenesis of atherosclerosis and discuss chemokines and chemokine receptors involved in lymphocyte homing to atherosclerotic lesions. We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis. Also, we review the role of their receptors CCR5, CCR6, CCR7, CXCR3, CXCR6, and CXCR2/CXCR4 and the role of the L-selectin in mouse models of atherosclerosis.

KEYWORDS:

CC chemokine receptor; atherosclerosis; lymphocytes

PMID:
25301842
PMCID:
PMC4429868
DOI:
10.1161/ATVBAHA.114.303227
[Indexed for MEDLINE]
Free PMC Article

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