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Twin Res Hum Genet. 2014 Oct;17(5):397-404. doi: 10.1017/thg.2014.54.

Genetic covariance between central corneal thickness and anterior chamber volume: a Hungarian twin study.

Author information

1
Department of Ophthalmology,Semmelweis University,Budapest,Hungary.
2
Department of Radiology and Oncotherapy,Semmelweis University,Budapest,Hungary.
3
Department of Political Science,Central European University,Budapest,Hungary.

Abstract

BACKGROUND:

Few, and inconsistent, studies have showed high heritability of some parameters of the anterior segment of the eye; however, no heritability of anterior chamber volume (ACV) has been reported, and no study has been performed to investigate the correlation between the ACV and central corneal thickness (CCT).

METHODS:

Anterior segment measurements (Pentacam, Oculus) were obtained from 220 eyes of 110 adult Hungarian twins (41 monozygotic and 14 same-sex dizygotic pairs; 80% women; age 48.6 ± 15.5 years) obtained from the Hungarian Twin Registry.

RESULTS:

Age- and sex-adjusted heritability of ACV was 85% (bootstrapped 95% confidence interval; CI: 69% to 93%), and 88% for CCT (CI: 79% to 95%). Common environmental effects had no influence, and unshared environmental factors were responsible for 12% and 15% of the variance, respectively. The correlation between ACV and CCT was negative and significant (r ph = -0.35, p < .05), and genetic factors accounted for the covariance significantly (0.934; CI: 0.418, 1.061) based on the bivariate Cholesky decomposition model.

CONCLUSION:

These findings support the high heritability of ACV and central corneal thickness, and a strong genetic covariance between them, which underscores the importance of identification of the specific genetic factors and the family risk-based screening of disorders related to these variables, such as open-angle and also angle closure glaucoma and corneal endothelial alterations.

PMID:
25300003
DOI:
10.1017/thg.2014.54
[Indexed for MEDLINE]

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