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Cell Host Microbe. 2014 Oct 8;16(4):433-7. doi: 10.1016/j.chom.2014.09.013.

Rethinking "enterotypes".

Author information

1
Department of Computer Science and Engineering, University of Minnesota, St. Paul, MN 55108, USA; BioTechnology Institute, University of Minnesota, St. Paul, MN 55108, USA.
2
BioTechnology Institute, University of Minnesota, St. Paul, MN 55108, USA.
3
Department of Computer Science and Engineering, University of Minnesota, St. Paul, MN 55108, USA.
4
Biofrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA.
5
Biofrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA; Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA; Department of Computer Science, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Boulder, CO 80309, USA. Electronic address: rob.knight@colorado.edu.

Abstract

Classification of the human gut microbiome into distinct types, or "enterotypes," provides an attractive framework for understanding microbial variation in health and disease. However, as discussed here, several different methods of collapsing enterotype variation into a few discrete clusters suggest that enterotype distribution is continuous and can vary widely within an individual.

PMID:
25299329
PMCID:
PMC5558460
DOI:
10.1016/j.chom.2014.09.013
[Indexed for MEDLINE]
Free PMC Article

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