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Structure. 2014 Oct 7;22(10):1373-4. doi: 10.1016/j.str.2014.09.003.

Caught in the act: multiple binding sites for memantine.

Author information

1
Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Jagtvej 160, 2100 Copenhagen, Denmark. Electronic address: stephan.pless@sund.ku.dk.

Abstract

In this issue of Structure, Ulens and colleagues demonstrate how an elegant combination of complementary functional and structural approaches can uncover both binding sites and conformational consequences associated with the Alzheimer's drug memantine binding to an ion channel.

PMID:
25295394
DOI:
10.1016/j.str.2014.09.003
[Indexed for MEDLINE]
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