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Int J Occup Environ Health. 2015;21(1):23-30. doi: 10.1179/2049396714Y.0000000085. Epub 2014 Oct 8.

Exposure to polycyclic aromatic hydrocarbons (PAHs) and bladder cancer: evaluation from a gene-environment perspective in a hospital-based case-control study in the Canary Islands (Spain).

Abstract

BACKGROUND:

Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to bladder cancer.

OBJECTIVE:

To evaluate the role of PAHs in bladder cancer, PAHs serum levels were measured in patients and controls from a case-control study.

METHODS:

A total of 140 bladder cancer patients and 206 healthy controls were included in the study. Sixteen PAHs were analyzed from the serum of subjects by gas chromatography-mass spectrometry.

RESULTS:

Serum PAHs did not appear to be related to bladder cancer risk, although the profile of contamination by PAHs was different between patients and controls: pyrene (Pyr) was solely detected in controls and chrysene (Chry) was exclusively detected in the cases. Phenanthrene (Phe) serum levels were inversely associated with bladder cancer (OR = 0·79, 95%CI = 0·64-0·99, P = 0·030), although this effect disappeared when the allelic distribution of glutathione-S-transferase polymorphisms of the population was introduced into the model (multinomial logistic regression test, P = 0·933). Smoking (OR = 3·62, 95%CI = 1·93-6·79, P<0·0001) and coffee consumption (OR = 1·73, 95%CI = 1·04-2·86, P = 0·033) were relevant risk factors for bladder cancer.

CONCLUSIONS:

Specific PAH mixtures may play a relevant role in bladder cancer, although such effect seems to be highly modulated by polymorphisms in genes encoding xenobiotic-metabolizing enzymes.

KEYWORDS:

Bladder cancer,; Gene-environment interaction; Polycyclic aromatic hydrocarbons,; Risk profession,

PMID:
25291984
PMCID:
PMC4273516
DOI:
10.1179/2049396714Y.0000000085
[Indexed for MEDLINE]
Free PMC Article

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