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Clin Nucl Med. 2015 Mar;40(3):247-9. doi: 10.1097/RLU.0000000000000595.

Primary Rosai-Dorfman disease of the bone in a patient with history of breast cancer: appearance on 99mTc-MDP scintigraphy, CT, and X-ray.

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From the *Department of Radiology, University of Washington, Seattle,WA; †Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY ‡IRCCS Fondazione SDN, Naples, Italy; §Department of Pathology, Western Washington Pathology, Multicare Health System, Tacoma; ∥PhenoPath Laboratories, Seattle; and ¶University of Washington, University of Washington Medical School, Seattle, WA.


A 49-year-old woman with history of breast cancer presented with pain at the level of the left anterior proximal tibia. An x-ray of the tibia demonstrated a lytic cortical lesion that prompted a whole-body 99mTc-MDP bone scan. The bone scan revealed intense bone remodeling at the level of the tibial lytic lesion and in the cervical spine. CT demonstrated an expansile lesion eroding the vertebral bodies of C6 and C7 with a large soft tissue component. A biopsy of the cervical spine mass demonstrated features diagnostic of Rosai-Dorfman disease without evidence of neoplastic cells.

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