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Curr Opin Immunol. 2014 Dec;31:44-50. doi: 10.1016/j.coi.2014.09.006. Epub 2014 Oct 4.

Distinct dendritic cell subsets actively induce Th2 polarization.

Author information

1
Committee on Immunology, University of Chicago, Chicago, IL, USA; Medical Scientist Training Program, University of Chicago, Chicago, IL, USA.
2
Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA. Electronic address: asperlin@uchicago.edu.

Abstract

The mechanisms by which dendritic cells induce Th2 polarization (DC(Th2) cells) have been controversial. Many have argued that DC(Th2) cells are not a distinct functional DC subset, but rather, DC-induced polarization of Th2 cells is a default pathway that occurs in the absence of inflammatory signals leading to DC-induced polarization of Th1/Th17 cells. However, recent studies demonstrate that distinct subsets of tissue DCs actively polarize Th2 cells after stimulation with type-2 inducing stimuli. DC(Th2) cells development is marked by the upregulation of specific transcription factors, cell surface molecules, and cytokines. These findings counter previous hypotheses that Th2 skewing by DCs is a passive response and support a model in which DCs are actively programmed to induce Th2 differentiation.

PMID:
25290173
PMCID:
PMC4737705
DOI:
10.1016/j.coi.2014.09.006
[Indexed for MEDLINE]
Free PMC Article

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