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Med Mycol. 2014 Nov;52(8):804-9. doi: 10.1093/mmy/myu059. Epub 2014 Oct 6.

High prevalence of Pneumocystis jirovecii colonization among HIV-positive patients in southern Brazil.

Author information

1
Pneumocystis Study Group, Infectious Diseases Unit, Hospital de Clínicas de Porto Alegre, Porto Alegre, Federal University of Rio Grande do Sul, Brazil.
2
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública and Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de Sevilla, Seville, Spain.

Abstract

A high prevalence of Pneumocystis jirovecii colonization was observed in patients positive for the human immunodeficiency virus (HIV) admitted to a tertiary hospital in southern Brazil between August 2012 and December 2012. Amplification of the mitochondrial large subunit ribosomal RNA gene in oropharyngeal samples through nested polymerase chain reaction identified P. jirovecii colonization in 26 of 58 (44.8%) HIV-positive patients admitted for causes other than Pneumocystis pneumonia. Colonization was more frequent among patients with an absolute CD4 count ≤200 cells/μl. These findings suggest that the HIV-infected population is a major reservoir and source of P. jirovecii infection and that identification of such individuals may contribute to future strategies for improving management of HIV-infected patients.

KEYWORDS:

HIV; Pneumocystis jirovecii; colonization

PMID:
25288653
DOI:
10.1093/mmy/myu059
[Indexed for MEDLINE]

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