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Trends Cell Biol. 2014 Nov;24(11):615-6. doi: 10.1016/j.tcb.2014.09.005. Epub 2014 Oct 3.

Brd4 is on the move during inflammation.

Author information

1
Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, NY 11794, USA.
2
Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address: vakoc@cshl.edu.

Abstract

Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.

KEYWORDS:

BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer

PMID:
25288306
PMCID:
PMC4252248
DOI:
10.1016/j.tcb.2014.09.005
[Indexed for MEDLINE]
Free PMC Article

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