Abstract
FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure (P = 0.01), breakthrough infections (P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Abdominal Abscess / drug therapy
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Abdominal Abscess / microbiology*
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Abdominal Abscess / mortality
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Abdominal Abscess / pathology
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Adult
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Aged
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Antifungal Agents / therapeutic use*
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Candida albicans / drug effects*
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Candida albicans / genetics
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Candida albicans / growth & development
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Candida glabrata / drug effects*
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Candida glabrata / genetics
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Candida glabrata / growth & development
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Candidiasis / drug therapy
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Candidiasis / microbiology*
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Candidiasis / mortality
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Candidiasis / pathology
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Drug Resistance, Fungal / genetics
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Echinocandins / therapeutic use*
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Female
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Humans
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Mutation
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Peritonitis / drug therapy
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Peritonitis / microbiology*
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Peritonitis / mortality
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Peritonitis / pathology
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Survival Analysis
Substances
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Antifungal Agents
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Echinocandins