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Antimicrob Agents Chemother. 2014 Dec;58(12):7586-91. doi: 10.1128/AAC.03936-14. Epub 2014 Oct 6.

Antibacterial properties of magnesium in vitro and in an in vivo model of implant-associated methicillin-resistant Staphylococcus aureus infection.

Author information

1
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
2
Department of Orthopaedic Surgery, the Central Hospital of Xuzhou, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou Hospital (affiliated with Medical College of Southeast University), Jiangsu, China.
3
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
4
Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China.
5
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China xinhua_qu@126.com krdai@163.com.

Abstract

Periprosthetic infection remains a challenging clinical complication. We investigated the antibacterial properties of pure (99.9%) magnesium (Mg) in vitro and in an in vivo rat model of implant-related infection. Mg was highly effective against methicillin-resistant Staphylococcus aureus-induced osteomyelitis and improved new peri-implant bone formation. Bacterial icaA and agr RNAIII transcription levels were also assessed to characterize the mechanism underlying the antibacterial properties of the Mg implant.

PMID:
25288077
PMCID:
PMC4249557
DOI:
10.1128/AAC.03936-14
[Indexed for MEDLINE]
Free PMC Article

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