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Pediatrics. 2014 Nov;134(5):e1441-6. doi: 10.1542/peds.2013-3900. Epub 2014 Oct 6.

Intravenous immunoglobulin therapy for refractory recurrent pericarditis.

Author information

1
Pediatric Rheumatology Unit and m.rosadelfresno@gmail.com.
2
Division of Pediatric Cardiology, Department of Pediatrics, Hospital Universitario Doce de Octubre, Madrid, Spain.
3
Pediatric Rheumatology Unit and.

Abstract

Recurrent pericarditis is a troublesome complication of idiopathic acute pericarditis and occurs more frequently in pediatric patients after cardiac surgery (postpericardiotomy syndrome). Conventional treatment with nonsteroidal antiinflammatory drugs, corticosteroids, and colchicine is not always effective or may cause serious adverse effects. There is no consensus, however, on how to proceed in those patients whose disease is refractory to conventional therapy. In such cases, human intravenous immunoglobulin, immunosuppressive drugs, and biological agents have been used. In this report we describe 2 patients with refractory recurrent pericarditis after cardiac surgery who were successfully treated with 3 and 5 monthly high-dose (2 g/kg) intravenous immunoglobulin until resolution of the effusion. Our experience supports the effectiveness and safety of this therapy.

KEYWORDS:

child; intravenous immunoglobulins; pericardial effusion/therapy; recurrent pericarditis

PMID:
25287461
DOI:
10.1542/peds.2013-3900
[Indexed for MEDLINE]
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