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Pharmacogenomics J. 2015 Jun;15(3):284-7. doi: 10.1038/tpj.2014.57. Epub 2014 Oct 7.

The first steps towards the era of personalised vaccinology: predicting adverse reactions.

Author information

1
Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universit√° di Milano, Milan, Italy.
2
Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy.
3
IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
4
1] Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy [2] Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University Hospital 'Luigi Sacco', Universit√° di Milano, Milan, Italy.

Abstract

Until now, the occurrence of adverse reactions among individuals inoculated with identical vaccines has been ascribed to unpredictable stochastic processes. Recent advances in pharmacogenomics indicate that some features of host response to immunisation are influenced by genetic traits, henceforth predictable. The ability to predict the adverse reaction to vaccination would represent an important step towards the development of personalised vaccinology and could enhance public confidence in the safety of vaccines. Herein, we have reviewed all the available information on the association between genetic variants and the risk for healthy subjects to develop adverse reactions.

PMID:
25287071
DOI:
10.1038/tpj.2014.57
[Indexed for MEDLINE]

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