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Nature. 1989 Sep 14;341(6238):125-30.

Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis.

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1
Institut für Physiologische Chemie der Universität München, FRG.

Abstract

Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding.

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PMID:
2528694
DOI:
10.1038/341125a0
[Indexed for MEDLINE]

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