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Neuroscience. 2015 Aug 27;302:103-11. doi: 10.1016/j.neuroscience.2014.09.061. Epub 2014 Oct 5.

Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy.

Author information

1
University of Kentucky, Sanders-Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA; The University of Manchester, Department of Biology, Manchester M13 9PL, United Kingdom.
2
University of Kentucky, Sanders-Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA.
3
University of Kentucky, Sanders-Brown Center on Aging, Department of Physiology, Lexington, KY 40536, USA. Electronic address: donna.wilcock@uky.edu.

Abstract

Neuroinflammation has long been known as an accompanying pathology of Alzheimer's disease. Microglia surrounding amyloid plaques in the brain of Auguste D were described in the original publication of Alois Alzheimer. It is only quite recently, however, that we have a more complete appreciation for the diverse roles of neuroinflammation in neurodegenerative disorders such as Alzheimer's. While gaps in our knowledge remain, and conflicting data are abound in the field, our understanding of the complexities and heterogeneous functions of the inflammatory response in Alzheimer's is vastly improved. This review article will discuss some of the roles of neuroinflammation in Alzheimer's disease, in particular, how understanding heterogeneity in the individual inflammatory response can be used in therapeutic development and as a mechanism of personalizing our treatment of the disease.

KEYWORDS:

Alzheimer’s; amyloid; cytokines; inflammation; microglia; phenotypes

[Indexed for MEDLINE]
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