Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?

Kazuki Miyaji; Nortina Shahrizaila; Thirugnanam Umapathi; Yee-Cheun Chan; Koichi Hirata; Nobuhiro Yuki

doi:10.1016/j.humimm.2014.09.010

Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?

Hum Immunol. 2014 Nov;75(11):1089-91. doi: 10.1016/j.humimm.2014.09.010. Epub 2014 Oct 5.

Authors

Kazuki Miyaji¹, Nortina Shahrizaila², Thirugnanam Umapathi³, Yee-Cheun Chan⁴, Koichi Hirata⁵, Nobuhiro Yuki⁶

Affiliations

¹ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
² Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
³ Department of Neurology, National Neuroscience Institute, Singapore.
⁴ Department of Medicine, National University Hospital, Singapore.
⁵ Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
⁶ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdcyuki@nus.edu.sg.

PMID: 25286001
DOI: 10.1016/j.humimm.2014.09.010

Abstract

Ezrin, radixin and moesin, which are strongly expressed in the Schwann cell microvilli, are putative targets for autoantibodies in acute or chronic inflammatory demyelinating polyneuropathy (AIDP or CIDP). An association between anti-moesin IgG antibodies and cytomegalovirus-related AIDP has been postulated. None of 41 AIDP patients, including 8 cytomegalovirus-related AIDP patients, and 23 CIDP had IgG or IgM antibodies to ezrin, radixin and moesin; whereas, one patient with cytomegalovirus-related AIDP had anti-ezrin IgM antibodies. Ezrin, radixin and moesin are unlikely targets for autoantibodies in AIDP and CIDP, and the association of anti-moesin antibodies with cytomegalovirus-related AIDP was not confirmed.

Keywords: Acute inflammatory demyelinating polyneuropathies; Chronic inflammatory demyelinating polyneuropathies; Ezrin; Moesin; Radixin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Autoantibodies / blood
Cytoskeletal Proteins / genetics*
Cytoskeletal Proteins / metabolism
Female
Gene Expression
Guillain-Barre Syndrome / blood
Guillain-Barre Syndrome / genetics*
Guillain-Barre Syndrome / immunology
Guillain-Barre Syndrome / pathology
Humans
Immunoglobulin G / blood
Immunoglobulin M / blood
Male
Membrane Proteins / genetics*
Membrane Proteins / metabolism
Microfilament Proteins / genetics*
Microfilament Proteins / metabolism
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / blood
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / genetics*
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / immunology
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / pathology

Substances

Autoantibodies
Cytoskeletal Proteins
Immunoglobulin G
Immunoglobulin M
Membrane Proteins
Microfilament Proteins
ezrin
moesin
radixin