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Theranostics. 2014 Sep 24;4(12):1233-8. doi: 10.7150/thno.10330. eCollection 2014.

A highly specific probe for sensing hydrogen sulfide in live cells based on copper-initiated fluorogen with aggregation-induced emission characteristics.

Author information

1
1. ZJU-ENS Joint Laboratory of Medicinal Chemistry, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
2
2. The Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
3
3. Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital and Department of Radiology, Harvard Medical School, 55 Fruit St., Boston, MA 02114, USA.

Abstract

Here we reported the first fluorescent probe with aggregation-induced emission characteristics, namely AIE-S, for the detection of hydrogen sulfide (H2S) in live cells. The detection system is selective for complicated biological application and the response is fast enough to complete within seconds. Moreover, the probe exhibits the unique advantage of being immune to aggregation-caused quenching which is a detrimental phenomenon limiting the application of most current available H2S fluorescent probes. The detection mechanism was investigated and postulated to be S(2-) initiated de-coordination and thereafter aggregation of the AIE-S complex.

KEYWORDS:

aggregation-induced emission; cell imaging; fluorescent probe; hydrogen sulfide

PMID:
25285171
PMCID:
PMC4184000
DOI:
10.7150/thno.10330
[Indexed for MEDLINE]
Free PMC Article

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