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Theranostics. 2014 Sep 19;4(12):1176-92. doi: 10.7150/thno.8715. eCollection 2014.

MicroRNAs associated with HBV infection and HBV-related HCC.

Author information

1
1. The Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China;
2
2. The Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;
3
3. The Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, China.

Abstract

Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of miRNAs in HBV infection, the recently identified mechanism underlying dysregulation of miRNAs in HBV-associated HCC, and their association with hepatocarcinogenesis. Moreover, we discuss the recent advances in the use of circulating miRNAs in the early diagnosis of HCC as well as therapies based on these aberrantly expressed miRNAs.

KEYWORDS:

Diagnosis; Hepatitis B virus; Hepatocellular carcinoma; MicroRNA; Therapy.

PMID:
25285167
PMCID:
PMC4183996
DOI:
10.7150/thno.8715
[Indexed for MEDLINE]
Free PMC Article

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