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Microbes Environ. 2014;29(4):427-30. doi: 10.1264/jsme2.ME14054. Epub 2014 Oct 4.

Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice.

Author information

1
Institute for Innovation, Ajinomoto Co., Inc.

Abstract

The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity.

PMID:
25283478
PMCID:
PMC4262368
DOI:
10.1264/jsme2.ME14054
[Indexed for MEDLINE]
Free PMC Article

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