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J Allergy Clin Immunol. 2014 Oct;134(4):831-835.e1. doi: 10.1016/j.jaci.2014.08.002.

Randomized trial of vitamin D supplementation for winter-related atopic dermatitis in children.

Author information

1
Massachusetts General Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Mass. Electronic address: ccamargo@partners.org.
2
Massachusetts General Hospital, Harvard Medical School, and Harvard School of Public Health, Boston, Mass; Health Sciences University of Mongolia, Ulaanbaatar, Mongolia.
3
Seattle Children's Hospital, Seattle, Wash.
4
Health Sciences University of Mongolia, Ulaanbaatar, Mongolia; National Dermatology Center, Ulaanbaatar, Mongolia.
5
Health Sciences University of Mongolia, Ulaanbaatar, Mongolia.

Abstract

BACKGROUND:

Epidemiologic and preclinical data, and a small randomized trial in Boston, suggest that vitamin D supplementation may improve winter-related atopic dermatitis (AD).

OBJECTIVE:

To determine the effect of vitamin D supplementation on winter-related AD.

METHODS:

We performed a randomized, double-blind, placebo-controlled trial of Mongolian children with winter-related AD (clinicaltrials.gov identifier: NCT00879424). Baseline eligibility included age 2 to 17 years, AD score 10 to 72 using the Eczema Area and Severity Index (EASI), and winter-related AD (eg, history of AD worsening during the fall-to-winter transition). Subjects were enrolled in Ulaanbaatar during winter and randomly assigned to oral cholecalciferol (1000 IU/day) versus placebo for 1 month. All children and parents received emollient and patient education about AD and basic skin care. The main outcomes were changes in EASI score and in Investigator's Global Assessment.

RESULTS:

The 107 enrolled children had a mean age of 9 years (SD 5), and 59% were male. Their median age of AD onset was 3 months (interquartile range 2 months to 1 year) and mean EASI score at baseline 21 (SD 9). One-month follow-up data were available for 104 (97%) children. Compared with placebo, vitamin D supplementation for 1 month produced a clinically and statistically significant improvement in EASI score (adjusted mean change: -6.5 vs -3.3, respectively; P = .04). Moreover, change in Investigator's Global Assessment favored vitamin D over placebo (P = .03). There were no adverse effects in either group.

CONCLUSION:

Vitamin D supplementation improved winter-related AD among Mongolian children, a population likely to have vitamin D deficiency in winter.

KEYWORDS:

Mongolia; Randomized controlled trial; atopic dermatitis; children; nutritional supplement; vitamin D; winter

PMID:
25282565
DOI:
10.1016/j.jaci.2014.08.002
[Indexed for MEDLINE]

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